Zero-order modified release solid dosage forms

Details Zero-order modified release solid dosage forms Zero-order modified release solid dosage forms

A - Human Necessities

61

K

A61K 9/24 (2006.01) A61K 9/36 (2006.01) A61K 31/4458 (2006.01)

Patent

CA 2651798

The invention comprises a solid dosage form for delivery of water soluble pharmaceutical agents. The solid dosage form comprises a matrix core containing the pharmaceutical agent and a hydrophobic material, and a coating containing a hydrophilic pore-forming agent and a hydrophobic polymer. The dosage form exhibits a zero-order release profile upon dissolution.

L'invention concerne une forme posologique solide pour la distribution d'agents pharmaceutiques solubles dans l'eau. La forme posologique solide de l'invention comprend un noyau matriciel contenant l'agent pharmaceutique et un matériau hydrophobe, et un enrobage contenant un agent hydrophile porogène et un polymère hydrophobe. Ladite forme posologique présente un profil de distribution d'ordre zéro après dissolution.

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