Zinc finger binding domains for tnn

Details Zinc finger binding domains for tnn Zinc finger binding domains for tnn

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 38/08 (2006.01) A61K 38/16 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2631422

Polypeptides that contain zinc finger-nucleotide binding regions that bind to nucleotide sequences of the formula TNN are provided. Compositions containing a plurality of polypeptides, isolated heptapeptides possessing specific binding activity, polynucleotides that encode such polypeptides and methods of regulating gene expression with such polypeptides, compositions and polynucleotides are also provided.

L'invention concerne des polypeptides qui contiennent des régions liant des nucléotides en doigt de zinc qui se lient à des séquences de nucléotides de formule TNN. L'invention concerne également des compositions contenant une pluralité de polypeptides, des heptapeptides isolés possédant une activité de liaison spécifique, des polynucléotides qui codent pour de tels polypeptides et des procédés de régulation de l'expression génique avec de tels polypeptides, de telles compositions et de tels polynucléotides.

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