Zinc finger domain libraries

Details Zinc finger domain libraries Zinc finger domain libraries

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C12N 15/10 (2006.01)

Patent

CA 2457095

Disclosed are libraries of chimeric zinc finger domains. The libraries can include two or more zinc finger domains from naturally occurring proteins, e.g., mammalian proteins and particularly human proteins. Useful chimeric zinc finger domains can be identified from the library. Also disclosed are the amino acid sequences of zinc finger domains that recognize particular sites.

Cette invention se rapporte à des bibliothèques de domaines à doigts de zinc chimériques. Ces bibliothèques peuvent contenir au moins deux domaines à doigts de zinc tirés de protéines naturelles telles que des protéines de mammifère et, particulièrement des protéines humaines. Des domaines à doigts de zinc chimériques utiles peuvent être identifiés dans cette bibliothèque. Cette invention concerne également les séquences d'acides aminés de domaines à doigts de zinc qui reconnaissent des sites particuliers.

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