Zinc finger protein derivatives and methods therefor

Details Zinc finger protein derivatives and methods therefor Zinc finger protein derivatives and methods therefor

C - Chemistry, Metallurgy

12

N

C12N 15/00 (2006.01) C07K 14/00 (2006.01) C07K 14/46 (2006.01) C07K 14/47 (2006.01) C12N 15/09 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 38/16 (2006.01)

Patent

CA 2181548

An assay is described which allows for identification of novel modulating zinc finger-nucleotide binding polypeptides. Such proteins are useful for inhibiting, activating or enhancing gene expression from a zinc finger-nucleotide binding motif containing promoter or other transcriptional control element, as well as a structural gene or RNA sequence. Also described are novel zinc finger-nucleotide binding polypeptides.

Cette invention concerne un dosage permettant d'identifier de nouveaux polypeptides de liaison de nucléotides à doigts zinciques de modulation. Ces protéines sont utiles pour inhiber, activer ou stimuler l'expression de gènes à partir d'un promoteur contenant un motif de liaison de nucléotides à doigts zinciques ou un autre élément de régulation de la transcription, ainsi qu'un gène de structure ou une séquence d'ARN. Cette invention concerne également de nouveaux polypeptides de liaison de nucléotide à doigts zinciques.

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