Zinc ionophores as anti-apoptotic agents

Details Zinc ionophores as anti-apoptotic agents Zinc ionophores as anti-apoptotic agents

A - Human Necessities

61

K

A61K 31/00 (2006.01) A61K 31/07 (2006.01) A61K 31/145 (2006.01) A61K 31/27 (2006.01) A61K 31/315 (2006.01) A61K 31/325 (2006.01) A61K 31/355 (2006.01) A61K 31/40 (2006.01) A61K 31/405 (2006.01) A61K 31/44 (2006.01) A61K 31/47 (2006.01) A61K 31/555 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2375852

The present invention provides methods and compositions comprising one or more zinc ionophores for blocking apoptosis in patients in need thereof. Concentrations of zinc-pyrithione and diethyl-dithiocarbamate in the picomolar to nanomolar range have a strong protective effect against apoptosis.

La présente invention concerne des procédés et des compositions comprenant un ou plusieurs ionophores de zinc destinés à inhiber l'apoptose chez des patients nécessitant un tel traitement. Des concentrations de pyrithione de zinc et de diéthyl-dithiocarbamate dans la plage picomolaire-nanomolaire produisent un effet protecteur important contre l'aopotose.

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