Zinc polyether antibiotics and their use as animal growth...

C - Chemistry – Metallurgy – 12 – P

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195/103, 260/210

C12P 17/18 (2006.01) A61K 31/55 (2006.01) C07D 491/113 (2006.01)

Patent

CA 1173385

ABSTRACT Zinc complexes of various monovalent and divalent polyether anitbiotics are provided which act as coccidio- state and growth promoting agents whn administered to poultry. Soluble zinc salt is added to a fermentation beer containing the polyether antibiotics to form an insoluble, recoverable biomass containing the desired zinc antibiotic complex. The polyether antibiotics which may be used to make the subject zinc complexes include: linear monovalent and divalent polyethers (monensin, nigericin, lasalocid, lyso- cellin, etc.); non-glycolic monovalent monoglycoside poly- ethers (septamycin, dianemycin, lenoremycin, carriomycin and antibiotic A-204); mononitrogen-containing divalent pyrrole ethers (calcimycin, X-14547, etc.); polynitrogen- containing divalent pyrrole ethers (A-23187, etc.); gly- colic monovalent monoglycoside polyethers (etheromycin, etc.); other polyether antibiotics including ionomycin, aabomycin, disnerycin, duamycin, BL-580, K-41, SF-1195, M-4164A, A-32887, 30,504RP, 38,986, 44,161, 47,433, 47,434 and 47,224. The above zinc complexes are active agents for improving cardiovascular function in animals.

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