Zinc salt compositions for the prevention of mucosal...

A - Human Necessities – 01 – N

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A01N 37/36 (2006.01) A61K 8/27 (2006.01) A61K 8/36 (2006.01) A61K 31/315 (2006.01) A61K 31/555 (2006.01) A61Q 19/00 (2006.01)

Patent

CA 2475224

The addition of low concentrations of combinations of water-soluble organic salts of zinc to gels, creams, lotions or ointments can increase the ability of these products to reduce or prevent exogenous irritants from causing irritation of the underlying substrate. The addition of low concentrations of combinations of water-soluble organic zinc salts to these gels, creams, lotions or ointments also can reduce the irritation of skin or mucous membranes caused by the addition of potentially-irritating substances such as spermicides, microbicides, fungicides or other therapeutic agents to the gel, cream, lotion or ointment. The advantages of this anti-irritant approach over others, which generally employ high concentrations of single zinc salts, are the reduced potential for zinc toxicity, the reduced potential for toxicity related to zinc itself, and the preservation of the desirable biological properties of potentially-irritating therapeutic substances added to the gel, cream, lotion or ointment.

L'invention concerne l'addition de faible concentrations de combinaisons de sels organiques de zinc, hydrosolubles, à des gels, crèmes, lotions ou à des onguents améliorant ces produits dans leur possibilité de diminuer ou d'empêcher que des irritants exogènes provoquent une irritation du substrat sous-jacent. L'addition de faible concentrations de combinaisons de sels organiques de zinc, hydrosolubles, à ces gels, crèmes, lotions ou à ces onguents permet aussi de réduire l'irritation de la peau ou des muqueuses provoquée par l'addition de substances potentiellement irritantes telles que des spermicides, microbicides, fongicides ou d'autres agents thérapeutiques aux gels, crèmes, lotions ou onguents. Les avantages de cette approche anti-irritation sur d'autres approches, qui généralement utilisent des concentrations élevées de sels de zinc uniques, comprennent le potentiel réduit concernant la toxicité du zinc, le potentiel réduit de toxicité liée au zinc lui-même, et la préservation des propriétés biologiques recherchées de substances thérapeutiques potentiellement irritantes ajoutées aux gels, crèmes, lotions ou onguents.

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