A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/663 (2006.01) A61P 19/08 (2006.01) A61P 19/10 (2006.01)
Patent
CA 2410201
Bisphosphonates, in particular more potent N-bisphosphonates such as zoledronic acid and derivatives, can be used with satisfactory results for prolonged inhibition of bone resorption in conditions of abnormally increased bone turnover, e.g. osteoporosis, by intermittent administration, wherein the periods between bisphosphonate administrations are longer than was previously considered appropriate, e.g. a dosing interval of at least about 6 months or less frequently.
L'utilisation de bisphosphonates, notamment des N-bisphosphonates plus puissants tels que l'acide zol~dronique et ses d~riv~s, donne des r~sultats satisfaisants s'agissant de l'inhibition ~ long terme de la r~sorption osseuse et ce, dans des situations caract~ris~es par un renouvellement exag~r~ des cellules osseuses, dans le cas de l'ost~oporose par exemple. On administre ces bisphosphonates de manire intermittente en allongeant le d~lai entre les prises par rapport ~ ce qu'il en est actuellement, en m~nageant, par exemple, un d~lai d'au moins 6 mois environ ou en adoptant un rythme moins fr~quent entre ces prises.
Horowitz Zebulun D.
Richardson Peter C.
Trechsel Ulrich
Fetherstonhaugh & Co.
Novartis Ag
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