C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/4709 (2006.01) A61P 9/00 (2006.01)
Patent
CA 2472342
A pharmaceutical composition comprising Zoniporide (N-(5-cyclopropyl-l- quinolin-5yl-lh-pyrazole-4-carbonyl)-guanidine) or its mesylate salt in the presence of an aqueous diluent in the ph range of 2 to 3.5.The composition is a sodium hydrogen exchange-1 (NHE-1)inhibitor for the prevention of,inter alia,perioperative myocardial ischemic injury in mammals.Moreover the application relates to a process for increasing the solubility of Zoniporide employing methanesulfonic acide
L'invention concerne une composition pharmaceutique comprenant du zoniporide (N-(5-cyclopropyl-l-quinolin-5yl-lh-pyrazole-4-carbonyl)-guanidine) ou son mésylate en présence d'un diluant aqueux, avec un pH compris entre 2 et 3,5. La composition constitue un inhibiteur d'échange-1 sodium/hydrogène (NHE-1) pour la prévention, inter alia, d'accident ischémique du myocarde périopératoire chez les mammifères. L'invention concerne, en outre, un procédé permettant d'augmenter la solubilité du zoniporide au moyen d'acide méthanesulfonique.
Arenson Daniel Ray
Pfizer Products Inc.
Smart & Biggar
LandOfFree
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