Ztnfr14, a tumor necrosis factor receptor

Details Ztnfr14, a tumor necrosis factor receptor Ztnfr14, a tumor necrosis factor receptor

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2542482

Novel tumor necrosis factor receptor (TNFR) polypeptides, polynucleotides encoding the polypeptides, antibodies and related compositions and methods are disclosed. The polypeptides may be used for detecting ligand, as well as agonists and antagonists. The polypeptides, polynucleotides and antibodies may also be used in methods that modulate tumor growth, metastasis, and immunity such as separating resting from stimulated immune cells.

L'invention porte sur de nouveaux polypeptides du récepteur du facteur de nécrose tumorale (TNFR), sur des polynucléotides codant les polypeptides, sur des anticorps et sur des compositions et méthodes apparentées. Les polypeptides peuvent être utilisés pour détecter un ligand, ainsi que des agonistes et des antagonistes. Les polypeptides, les polynucléotides et les anticorps peuvent être également utilisés dans des procédés qui modulent la croissance tumorale, la métastase et l'immunité tels que la séparation résultant des cellules immunes stimulées.

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