Zwitterionic compounds and their n-halo derivatives for use...

Details Zwitterionic compounds and their n-halo derivatives for use... Zwitterionic compounds and their n-halo derivatives for use...

A - Human Necessities

61

K

A61K 31/185 (2006.01) A61K 31/195 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01)

Patent

CA 2048068

ABSTRACT ZWITTERIONIC COMPOUNDS AND THEIR N-HALO DERIVATIVES FOR USE IN THE TREATMENT OF CLINICAL CONDITIONS Zwitterionic compounds selected from: taurine (2-aminoethanesulphonic acid), 2(N-morpholino)ethanesulphonic acid (MES), N-(2-acetamido)iminodiacetic acid (ADA), piperazine-N,N'bis(2-ethanesulphonic acid (PIPES), N-(2-acetamido)-2-aminoethanesulphonic acid (ACES), N,N-bis(2-hydroxyethyl)-2-aminoethanesulphonic acid (BES), 3-(N-morpholino)propanesulphonic (MOPS), N-N[tris(hydroxymethyl)-methyl]-2-aminoethanesulphonic acid (TES), N-2-hydroxyethylpiperazine-N'-2-ethanesulphonic acid (HEPES), N-2-hydroxyethylpiperazine-N'3-propanesulphonic acid ((H)EPPS), 2-(cyclohexylamino) ethanesulphonic acid (CHES) or 3-(cyclohexylamino)propanesulphonic acid (CAPS), and their N-halo derivatives can be used separately or in combination in the treatment of related clinical conditions by stimulating myeloperoxidase activity, which in turn stimulates hypochlorous acid production in vivo, which leads inter alia to enhanced leukotriene inactivation.

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