Zwitterionic forms of trovafloxacin

Details Zwitterionic forms of trovafloxacin Zwitterionic forms of trovafloxacin

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/435 (2006.01)

Patent

CA 2229786

A zwitterionic form of trovafloxacin having formula (I) selected from the group consisting of its crystalline hygroscopic and non-hygroscopic polymorphs and pentahydrate and methods for their preparation. The invention further relates to methods of using, and pharmaceutical compositions comprising, the compounds of the invention for treatment of bacterial infections in mammals.

On décrit une forme zwittérionique de trovafloxacine possédant la formule (I) et choisie dans le groupe constitué par des polymorphes cristallins de celle-ci, hygroscopiques et non hygroscopiques, et par un pentahydrate de celle-ci. On décrit également des procédés de préparation de ces composés, des procédés d'utilisation de ceux-ci, ainsi que des compositions pharmaceutiques contenant ces composés et servant au traitement d'infections bactériennes chez les mammifères.

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