C - Chemistry – Metallurgy – 08 – F
Patent
C - Chemistry, Metallurgy
08
F
C08F 220/06 (2006.01) C08F 228/02 (2006.01) C08F 230/02 (2006.01) C08F 238/00 (2006.01)
Patent
CA 2745302
The invention generally relates to zwitterionic polymers (including zwitterionic copolymers), such as polymethacrylic structures, with pendent functional moieties, such as therapeutic or biologic moieties. More particularly, the invention relates to phosphorylcholine- substituted methacrylic polymers prepared by free radical polymerization and click chemistry, for example, and compositions and products comprising same, as well as related methods and uses of the compositions, for example, as biological or therapeutic agents and in drug delivery thereof.
L'invention concerne généralement des polymères zwitterioniques (y compris des copolymères zwitterioniques), notamment des structures polyméthacryliques, qui présentent des fractions fonctionnelles latérales, telles des fractions thérapeutiques ou biologiques. En particulier, l'invention concerne des polymères méthacryliques à substitution phosphorylcholine préparés par une polymérisation par radicaux libres et par chimie click, par exemple. L'invention concerne également des compositions et des produits comprenant lesdits polymères, ainsi que des procédés associés et des utilisations de ces compositions servant, par exemple, d'agents thérapeutiques ou biologiques, et servant à l'administration de médicaments.
Chen Xiangji
Emrick Todd
Mcrae Samantha
Gowling Lafleur Henderson Llp
University Of Massachusetts
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