Tri-py-ceph combo

C - Chemistry – Metallurgy – 07 – D

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C07D 501/18 (2006.01)

Patent

CA 1147724

ABSTRACT The specification discloses a compound having the formula Image 1 wherein A is Image or Image wherein R1 is hydrogen or formyl; R is Image or Image ; Y is hydrogen, chlorine, bromine, fluorine, trifluoro- methyl, amino, nitro, hydroxy, (lower) alkyl of 1-4 carbon atoms or (lower)alkoxy of 1-4 carbon atoms; R2 is (lower) alkyl of 1-4 carbon atoms and wherein A1 is methyl or -(CH2)n COOH and n is one or two; or an easily hydrolyzed ester or nontoxic pharmaceutically acceptable salt thereof. The specification further discloses a compound of formula I wherein A is H. There is also disclosed a process for the preparation of the compounds, an easily hydrolyzed ester or nontoxic pharmaceutically acceptable salt thereof. The compound of the formula I according to the present invention is effective in the treatment of bacterial infections in man.

402557

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