1-substituted-4-(1,2-diphenylethyl)piperazine derivatives...

Details 1-substituted-4-(1,2-diphenylethyl)piperazine derivatives... 1-substituted-4-(1,2-diphenylethyl)piperazine derivatives...

C - Chemistry, Metallurgy

07

D

260/267.1

C07D 295/00 (2006.01) C07D 295/03 (2006.01) C07D 295/096 (2006.01)

Patent

CA 1084499

1-SUBSTITUTED-4-(1,2-DIPHENYLETHYL)PIPERAZINE DERIVATIVES AND COMPOSITIONS CONTAINING THE SAME Abstract of the Disclosure: 1-Substituted-4-(1,2-diphenylethyl)piperazine de- rivatives of the formula: Image wherein X is 2- or 3-hydroxy, 2-methoxy, 3-methyl, 3-alkoxy having 1 to 4 carbon atoms, or 2- or 3-alkanoyloxy having 2 to 5 carbon atoms; R is allyl, 3-hydroxyisoamyl, 3-methyl- 2-butenyl, 3-methyl-3-butenyl, propyl, an unsubstituted mono- cycloalkyl having 5 to 8 carbon atoms, 2-chlorophenyl, or a phenyl substituted by hydroxy or methoxy; with proviso that when X is a substituent at position 2, R is cyclohexyl and when X is 3-methyl, R is 2-methoxyphenyl or an unsubstituted monocycloalkyl having 6 to 8 carbon atoms, and their pharma- ceutically acceptable salts, and the preparation thereof, and analgesic or antitussive compositions containing the same as the essentially active ingredient. - 1 -

247050

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