Steroidal ¬16.alpha., 17-b|naphthaleno and...

Details Steroidal ¬16.alpha., 17-b|naphthaleno and... Steroidal ¬16.alpha., 17-b|naphthaleno and...

C - Chemistry, Metallurgy

07

J

260/59

C07J 7/00 (2006.01) C07J 13/00 (2006.01) C07J 41/00 (2006.01) C07J 53/00 (2006.01)

Patent

CA 1142916

K570 ABSTRACT STEROIDAL[l6.alpha.,l7-b]CYCLOHEXENE AND NAPHTHALENO-21- CARBOXYLIC ACIDS AND ESTERS Steroids having the formula Image and esters thereof wherein X is hydrogen or halogen; Y is hydrogen, methyl or fluorine; R4 is chlorine, fluorine or hydroxy and R5 is hydrogen or R4 and R5 together are =O; R2 and R3 are the same or different and are hydrogen, alkyl or aryl or taken together with the double bond to which they are attached form a benzene ring; R6 are R7 are the same or different and are hydrogen, alkyl, alkoxy, formyl, Image , phenyl or cyano and in addition hydroxy, halogen carboalkoxy and alkylcarbonyl when R2 and R3 are separate with the proviso that when R6 and R7 are different, one of R6 and R7 is hydrogen; R8 is hydrogen or Image wherein R9 and R10 are the same or different and are hydrogen or alkyl have useful antiinflammatory activity.

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