Process for preparation of quinazolines

Details Process for preparation of quinazolines Process for preparation of quinazolines

C - Chemistry, Metallurgy

07

D

204/91.17

C07D 239/72 (2006.01) C07D 239/82 (2006.01) C07D 401/06 (2006.01) C07D 409/06 (2006.01)

Patent

CA 1047967

A PROCESS FOR PREPARATION OF QUINAZOLINES ABSTRACT OF THE DISCLOSURE Quinazoline derivatives of the formula, Image [I] wherein R1, R2 and R3 are independently a hydrogen atom, a halogen atom, a trifluoromethyl group, a nitro group, a lower alkylsulfonyl group, a lower alkyl group, a lower alkoxy group or a lower alkylthio group; and R4 is a hydrogen atom, a lower alkyl group, an aralkyl group, a lower alkanoyloxyalkyl group, a lower alkoxy- alkyl group, a polyhaloalkyl group, a cycloalkyl group, a cycloalkylalkyl group, a tetrahydrofurfuryl group, a tetrahydropyranylmethyl group, a pyridylmethyl group, a furylmethyl group or a thienylmethyl group, are prepared by irradiating a dihydroquinazolinone derivative of the formula, Image wherein R1, R2, R3 and R4 are as defined above, with light. These quinazoline derivatives are useful as an ani-inflammatory agent, anti-viral agent, uricosuric agent and intermediates for other useful anti-inflammatory agents.

228044

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