Ergoline i derivatives

Details Ergoline i derivatives Ergoline i derivatives

C - Chemistry, Metallurgy

07

D

260/206

C07D 457/00 (2006.01) C07D 457/04 (2006.01) C07D 457/06 (2006.01) C07D 457/12 (2006.01)

Patent

CA 1092100

ERGOLINE I DERIVATIVES Abstract of the Disclosure The present invention provides compounds of formula I, Image I wherein X is hydrogen, chlorine or bromine, R1 is methyl or ethyl, R2 is alkyl of 1 to 4 carbon atoms or allyl, R3 is CH2CN or a group -NR4R5, wherein R4 is hydrogen or alkyl of 1 to 4 carbon atoms, and R5 is alkanoyl of 1 to 5 carbon atoms, alkoxycarbonyl of 2 to 5 carbon atoms in the aggregate thereof, or mono-, di- or tri-haloalkoxycarbonyl of 3 to 5 carbon atoms, wherein the alkoxy qroup is substituted by halogen other than in the .alpha. position to the oxygen atom, or R5 is SO2R6, wherein R6 is alkyl of 1 to 4 carbon atoms, mono-, di- or tri-haloalkyl of 1 to 4 carbon atoms, phenyl, phenyl mono- substltuted by halogen or alkoxy of 1 to 4 carbon atoms, or pyridyl, or R6 is a group NR7R8, wherein R7 and R8 are, independently, hydrogen or alkyl of 1 to 4 carbon atoms, or R7 and R8 together form -[CH2]n- or -[CH2]2-A-[CH2]2-, wherein n is a whole number from 3 to 7, and A is oxygen, sulphur, or nitrogen substituted by alkyl of 1 to 4 carbon atoms, or phenyl; which are useful as prolactin inhibitors, anti-parkinson agents, and anti-depressants.

268415

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