Arylpiperazine derivatives of adenine

Details Arylpiperazine derivatives of adenine Arylpiperazine derivatives of adenine

C - Chemistry, Metallurgy

07

D

260/242.3

C07D 473/34 (2006.01) A61K 31/395 (2006.01) A61K 31/50 (2006.01) A61K 31/52 (2006.01) C07D 241/04 (2006.01) C07D 295/04 (2006.01) C07D 295/12 (2006.01) C07D 403/06 (2006.01) C07D 403/14 (2006.01) C07D 405/06 (2006.01) C07D 473/00 (2006.01) C07D 475/06 (2006.01)

Patent

CA 1036595

ABSTRACT OF THE DISCLOSURE New aryl-piperazine derivatives of adenine and their process of preparation are provided, the derivatives have the formula (I): Image (I) wherein R1 is a hydrogen atom or a lower alkyl radical, R2 is selected from a lower alkyl radical, a lower alkenyl radical, a cyclo-lower-alkyl radical, an aryl radical and a lower alkyl radical substituted by at least one of phenyl and hydroxyl; or R1 and R2, together with the nitrogen atom to which they are attached, represent a piperidine, pyrrolidine or morpholine ring; and R3 is selected from a hydrogen atom, a halogen atom, a lower alkyl radical, and a lower alkoxy radical; and the pharmaceutically acceptable, pharmacologically compatible acid addition salts thereof; the derivatives have an anti-oedematous action and reduce the capillary permeability; they can suppress the liberation and the action of histamine and serotonin and thus have an anti-inflammatory and anti-allergic action.

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