C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/323, 260/352
C07D 207/273 (2006.01) C07C 205/56 (2006.01) C07D 295/26 (2006.01) C07D 307/33 (2006.01) C07D 307/58 (2006.01) C07D 317/28 (2006.01) C07D 319/06 (2006.01)
Patent
CA 1117951
Abstract of the Disclosure This application relates to benzenesulfonamide derivatives having an outstanding salidiuretic action. The compounds have the formula I Image I wherein R1 represents hydrogen, alkyl or alkenyl with 1 to 4 carbon atoms, and the alkyl radical may carry a methoxy group, cycloalkyl with 3 to 5 ring members or benzyl, R2 to R6 repre- sents hydrogen or an alkyl radical with 1 to 4 carbon atoms, R7 repre- sents hydrogen, alkyl with 1 to 10 carbon atoms, and the alkyl radical may carry 1 to 2 methoxy or ethoxy groups or an ethylenedioxy or propylenedioxy group, alkenyl with 3 to 5 carbon atoms, cycloalkyl with 3 to 12 ring members, which is optionally substituted by a methyl group, cycloalkylalkyl with 5 or 6 ring members and with 1 or 2 carbon atoms in the alkyl part, phenylalkyl with 1 to 2 carbon atoms in the alkyl part, and the phenyl radical may be monosubstituted or disubstituted and carry methyl, methoxy or chlorine as substituents, or R6 and R , together with the N atom, also denote a saturated 5- membered to 6-membered heterocyclic ring and Y denotes halogen, hydrogen, trifluoromethyl or methyl. The compounds also exist in the form of tautomers. Some of the compounds exhibit a significant increase in the excretion of uric acid and the uric acid clearance. They are distinguished by a long-lasting period of action and are suitable for the treatment of hypertonic conditions in humans, optionally in combination with anti- hypertonic agents.
309538
Hropot Max
Lang Hans-Jochen
Muschaweck Roman
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Hoechst Aktiengesellschaft
LandOfFree
Benzenesulfonamide derivatives and processes for their... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Benzenesulfonamide derivatives and processes for their..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzenesulfonamide derivatives and processes for their... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1059692