Sulfur containing octapeptide derivatives

Details Sulfur containing octapeptide derivatives Sulfur containing octapeptide derivatives

C - Chemistry, Metallurgy

07

K

530/7.06

C07K 7/14 (2006.01) C07K 5/083 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1064913

Abstract of the Disclosure Octapeptide derivatives of the general formula Image wherein X is a sarcosine or aspartic acid residue, Y is the residue of isoleucine or valine, A is thio, sulfinyl or sulfonyl, and R is benzyl, are potent inhibitors of the pharma- cological effects of Angiotensin and possess the additional advantage of a favourable antagonist/agonist ratio.

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