Extraction of protective antigen from b pertussis and antigen

A - Human Necessities – 61 – K

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167/137

A61K 39/10 (2006.01)

Patent

CA 1059027

EXTRACTION OF PROTECTIVE ANTIGEN FROM B PERTUSSIS AND ANTIGEN Abstract of the disclosure This application is directed to a process for the preparation of a protective antigen from Bordetella pertussis in which pathogens of Bordetella pertussis are mixed with an aqueous solution of a denaturizing agent and a neutral salt. The resultant liquid supernatant which comprises an aqueous suspension of the protective antigen containing denaturizing agent is separated from the residue of pathogens and the denaturizing agent is then separated from the aqueous suspension. A protective antigen is obtained which can be used in the prepa- ration of a pertussis vaccine.

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