Preparation of 2,1,4-benzothiadiazine derivatives

Details Preparation of 2,1,4-benzothiadiazine derivatives Preparation of 2,1,4-benzothiadiazine derivatives

C - Chemistry, Metallurgy

07

D

260/243.2

C07D 285/22 (2006.01)

Patent

CA 1056828

ABSTRACT This invention is directed to the preparation of a 2,1,4-benzothiadiazine derivative by (a) a process in which an o-nitro-phenyl-thionocarbamoyl carbamate is reduced by means of an alkali metal dithionite in an alkaline solution or (b) a process in which a 2,1,4- benzothiadiazine having specific substituents is oxidized with a per-acid. These products are intermediates in the preparation of 2-carbalkoxy-amino-benzimidazoyl- 5(6)-phenyl ethers and thioethers which are valuable chemotherapeutic agents for use in treating diseases caused by parasites in humans and animals.

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