Digoxin derivatives

Details Digoxin derivatives Digoxin derivatives

C - Chemistry, Metallurgy

07

D

260/8

C07D 493/22 (2006.01) C07J 41/00 (2006.01)

Patent

CA 1140109

ABSTRACT The present invention provides 12-dehydrodigoxin oximes of the general formula:- Image wherein R1 and R2, which can be the same or different, are hydrogen atoms, lower acyl radicals or lower alkyl radicals or R1 and R2 together can represent an alkylidene radical containing 2 to 6 carbon atoms and R3 is a hydrogen atom or a lower alkyl or aralkyl radical. The present invention also provides a process for the preparation of these oximes and pharmaceutical compositions containing them and is also concerned with the use of these oximes for the preparation of pharma- ceuticals for the treatment of cardiac insufficiency.

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