Process for the preparation of new pyridine derivatives

Details Process for the preparation of new pyridine derivatives Process for the preparation of new pyridine derivatives

C - Chemistry, Metallurgy

07

D

260/276.1

C07D 495/04 (2006.01) C07D 491/048 (2006.01) C07D 493/04 (2006.01)

Patent

CA 1042438

ABSTRACT OF THE DISCLOSURE This invention relates to a process for the preparation of new pyridinium derivatives having the formula Image (I) in which X represents oxygen or sulfur; R represents a phenyl which may be substituted by halogen, alkyl containing 1 to 6 carbon atoms, alkoxy contain- ing 1 to 6 carbon atoms, nitro, or hydroxy; or benzoyl which may be substi- tuted by halogen, alkyl containing 1 to 6 carbon atoms, alkoxy containing 1 to 6 carbon atoms, nitro, or hydroxy; R1 represents hydrogen, hydroxy, or alkyl containing 1 to 6 carbon atoms, R2 represents hydrogen or halogen; and n is one or two; and in which the symbols R1 may have different meanings in each radical -(CHR1)- when n is two; and Z is halogen; their pharmaceutically acceptable acid addition and quaternary ammonium salts. Said derivatives are therapeutically useful for their anti-arrhythmic action and constitute useful chemical intermediates for the preparation of medicinally useful pyridine derivatives.

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