C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
260/2
C07J 5/00 (2006.01) C07J 1/00 (2006.01) C07J 7/00 (2006.01) C07J 13/00 (2006.01) C07J 21/00 (2006.01) C07J 41/00 (2006.01) C07J 53/00 (2006.01) C07J 63/00 (2006.01) C07J 71/00 (2006.01)
Patent
CA 1164859
ABSTRACT OF THE DISCLOSURE The present invention provides a process for the preparation of a 6-methylene-.DELTA.4-3-keto steroid of general Partial Formula I Image (I), wherein R is hydrogen or an acyloxy or alkoxy group of up to 6 carbon atoms and R' is the CD-ring skeleton of a steroid of the androstane or pregnane series, which comprises treating a .DELTA.4-3-keto steroid of general Partial Formula II Image (II), wherein R and R' have the meanings given above, in an inert solvent, with a condensation agent at a temperature from 0-80°C together with a formaldehyde derivative of the formula X(CH2O)nY wherein X is alkoxy and Y is alkyl of up to 5 carbon atoms when n is 1, or X and Y represent a C-O single bond, when n is 3, or X is hydroxy and Y is hydrogen when n is an integer of about 100-1000.
370152
Annen Klaus
Hofmeister Helmut
Laurent Henry
Wiechert Rudolf
Marks & Clerk
Schering Aktiengesellschaft
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