Piperidinopropyl derivatives

Details Piperidinopropyl derivatives Piperidinopropyl derivatives

C - Chemistry, Metallurgy

07

D

260/261, 260/278

C07D 211/26 (2006.01) C07C 205/56 (2006.01) C07D 211/22 (2006.01) C07D 401/12 (2006.01)

Patent

CA 1115703

ABSTRACT The present invention provides piperidinopropyl derivatives of the formula:- Image wherein R1 and R2, which can be the same or different, are hydrogen atoms or lower alkyl radicals or together represents an alkylene radical, R3 is a hydrogen atom or -O-R5, R5 being a hydrogen atom or an acyl radical,R4 is a hydrogen atom or a formyl radical, A is an -X1=Y1- grouping, in which X1 and Y1, which can be the same or different, are nitrogen atoms or -C(R6)=, in which R6 is hydrogen atom, a lower alkyl radical optionally substituted by -O-R5, wherein R5 is as defined above a carboxyl or an alkoxy carbonyl radical; or A is an -X2-Y2- grouping, in which X2 is -CH2- or -N(R7)-, in which R7 is a hydrogen atom or a lower alkyl radical, and Y2 is -CH2- or -C(=Z)-, in which Z is an oxygen or sulphur atom; or A is a -CR8=CR9- grouping, in which R8 and R9 together represent a -CH=CH-CH=CH- bridge, with the proviso that Y1 or Y2 is connected to >N-R4 in the above-given formula, and B is a heterocyclic radical or, if A represents -X2-Y2- or -CR8=CR9-, also a phenyl radical, which are optionally substituted one or more times by halogen, hydroxyl or lower alkyl, which optionally carries a hydroxyl group or a carboxamido radical, or by a lower alkoxy, amino carboxamido, lower alkylcarbonylamino, acyl or lower alkylsulphonylamino radical; and the pharmacologically acceptable salts thereof. The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them. Furthermore, the present invention is concerned with the use of these compounds for the treatment of cardiac and circulatory diseases.

344561

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