Psychopharmacologically active peptides and peptide...

Details Psychopharmacologically active peptides and peptide... Psychopharmacologically active peptides and peptide...

C - Chemistry, Metallurgy

07

K

530/7.02, 530/7.

C07K 14/695 (2006.01) C07K 5/103 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1100947

ABSTRACT OF THE DISCLOSURE Biologically active novel peptides and peptide-derivatives of the general formula: Image I where A represents H-(L or D)Met, H-(L or D)Met(?O), H-(L or D)Met(?O2) desamino-Met, desamino-Met(?O), desamino-Met(?O2) or the group H2N-B-CO-; B represents a branched or straight-chain alkylene (C1-C6) or alkylidene (C1-C6) group; Q represents the amino-acid residue -NH-CHR-CO-; R represents alkyl (C1-C6), p-hydroxyphenylmethyl, 3-indolylmethyl or phenylmethyl; R1 and R2 represent hydrogen or an alkyl(1-6C) group, and Z represents N-(phenylalkyl)amino, N-(.beta.-indolylalkyl)amino, L-Trp-OH, L-Phe-OH, L-Trp-Gly-OH or L-Phe-Gly-OH, as well as the functional derivatives thereof. They are useful for their psychopharmacological properties, in particular inhibiting the extinction of the conditioned flight response.

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