Thermostable human cu/zn superoxide dismutase muteins

C - Chemistry – Metallurgy – 12 – N

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195/39.1, 195/1.

C12N 15/01 (2006.01) C12N 1/19 (2006.01) C12N 9/02 (2006.01) C12N 15/12 (2006.01) A61K 37/50 (1990.01)

Patent

CA 1289092

THERMOSTABLE HUMAN Cu/Zn SUPEROXIDE DISMUTASE MUTEINS Abstract Thermostable muteins of human Cu/Zn superoxide dismutase (hSOD) in which one or both of the free cysteine residues at positions 6 and 111 are replaced with an uncharged amino acid. hSOD Ala6, hSOD Serlll, and hSOD Ala6 Serlll are specifically exemplified.

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