Polymeric single layer analytical element

Details Polymeric single layer analytical element Polymeric single layer analytical element

G - Physics

01

N

150/14, 150/3, 1

G01N 33/52 (2006.01) C12Q 1/00 (2006.01) G01N 33/72 (2006.01) G01N 33/84 (2006.01)

Patent

CA 1260387

ABSTRACT Disclosed is a device for determining an analyte in a fluid sample, which device consists essentially of a dimen- sionally stable, uniformly porous, diffusely reflective single layer formed of a polymeric non-fibrous matrix and, dispersed throughout said matrix, at least one substance which effects a detectable response to the analyte. Prefer- ably, the polymer is a high density polyethylene treated to be hydrophilic. The optical properties of the device can be further modified by blending in pigments, such as titanium dioxide. The analyte-responsive substance can include a first component which is responsive to the analyte to form a reaction product and a second component separated from the first component binder and responsive to the reaction product to effect a detectable change. The device is completely effective in the absence of other elements or structures to provide a quantitative detectable response to the presence of the analyte under assay.

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