Radiolabeled amine compounds and their use

Details Radiolabeled amine compounds and their use Radiolabeled amine compounds and their use

G - Physics

01

N

260/472, 260/595

G01N 33/60 (2006.01) A61K 51/04 (2006.01)

Patent

CA 1204769

ABSTRACT OF THE DISCLOSURE Disclosed are radiolabeled amine compounds, methods for preparing these compounds, diagnostic compositions containing the radiolabeled amine compounds and methods for using these compositions in conducting radiodiagnostic examinations for determining the location and extent of an occurring blood clot in the body of a warm-blooded animal such as a human. The radiolabeled amine compounds of the present invention have the general formula; Image wherein X is selected from the group consisting of oxygen; sulfur; lower alkylene, radioactive selenium; and radioactive tellurium, Y is a hydrocarbyl amino group, and when X is oxygen, sulfur o lower alkylene, Y is a radioactive iodine-substituted hydrocarbyl amino group. Also disclosed are pharmaceutically-acceptable, acid addition salts of the above radiolabeled amine compounds.

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