3-0-demethyl derivatives of the istamycin b series of...

Details 3-0-demethyl derivatives of the istamycin b series of... 3-0-demethyl derivatives of the istamycin b series of...

C - Chemistry, Metallurgy

07

H

260/358.5

C07H 15/22 (2006.01)

Patent

CA 1188309

3-0-DEMETHYL DERIVATIVES OF THE ISTAMYCIN B SERIES OF COMPOUNDS AND THEIR PREPARATION ABSTRACT OF THE DISCLOSURE New derivatives of the istamycin B series of compounds are provided, which are 3-0-demethylistamycin B0, 3-0-demethyl- istamycin B and 3-0-demethyl-2"-N-formimidoylistamycin B repre- sented generally by Formula I or specifically by Formulae Ia, Ib and Ic, respectively. Compound Ia is useful as an intermediate for the preparation of Compounds Ib and Ic and the latter two compounds exhibit a high antibacterial activity against a wide variety of Gram-positive and Gram-negative bacteria and are use- ful antibiotics. Also provided are processes for the prepara- tion of the new derivatives starting from istamycin B0.

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