Prostaglandins

Details Prostaglandins Prostaglandins

C - Chemistry, Metallurgy

07

C

167/205, 167/246

C07C 337/08 (2006.01) A61K 31/557 (2006.01) C07C 59/80 (2006.01) C07C 62/34 (2006.01) C07C 62/36 (2006.01) C07C 405/00 (2006.01) C07D 493/08 (2006.01)

Patent

CA 1274512

ABSTRACT PROSTAGLANDINS Novel compounds have the formula (I) Image (I) where Image represents one of the divalent cyclic groups Image the letters a and b indicating in each case the points of attachment of the substituents R1 and CV(R2)-NV'R, respectively; R1 is a group -(CH2)b-(A)a-(CH2)c-B-CH2-CO2R' in which A and B are each separately oxygen or sulphur, a is 0, b is 0 and c is an integer from 3 to 10, or a is 1, b is 0 or an integer from 1 to 7 and c is an integer from 2 to 9 with the sum of b and c being from 2 to 9, and CO2R' is a carboxy group or an amide, ester or salt derivative thereof; V and V' either each separately is hydrogen or together are the second bond of a carbon-nitrogen double bond; R2 is hydrogen, an aliphatic hydrocarbon group or an aliphatic hydrocarbon group substituted by an aromatic group directly or through an oxygen or sulphur atom; and R is a group -OR3, -OR4, -D-R3, -N=R5 or -NW.G.W' in which D is -NH-, -NH.CS-, -NH.CO-, -NH.CO.CH2N(R6)-, -NH.SO2-, -NH.CO.NH-, -NH.CS.NH-, -NH.CO.O- or -NH.CS.O, G is -CO- or -CS- and W and W' together are a group -(CH2)d- in which d is 3, 4, or 5, R3 is an aliphatic hydrocarbon group, an aromatic group or an aliphatic hydrocarbon group substituted by one or more aromatic groups directly or through an oxygen or sulphur atom, R4 is an aliphatic hydrocarbon group which is substituted through an oxygen atom by an aliphatic hydrocarbon group which is itself substituted directly by one or more aromatic groups, R5 is an aliphatic hydrocarbon group, an aromatic group in which the .pi.-electron system is not fully delocalised over the entire ring system, or an aliphatic hydrocarbon group substituted by one or more aromatic groups directly or through an oxygen or sulphur atom, and R6 is hydrogen, an aliphatic hydrocarbon group, an aromatic group or an aliphatic hydrocarbon group substituted by one or more aromatic groups directly or through an oxygen or sulphur atom. The compounds are of value for use in pharmaceutical compositions particularly in the context of the inhibition of thromboxane activity.

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