C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
260/230.52
C07H 15/22 (2006.01) C07H 15/224 (2006.01)
Patent
CA 1175818
ABSTRACT OF THE DISCLOSURE New, useful derivatives of istamycins A and B are provided, which are formimidoylistamycins A and B of formula (I) having a toxicity significantly lower than those of istamycins A and B with an antibacterial activity higher than that of fortimicin A and of the same level as those of istamycins A and B. These compounds may be pre- pared by reacting 1,2',6'-tri-N-protected istamycins A and B of formula (V) with an iminoether.
374402
Kondo Shinichi
Okami Yoshiro
Umezawa Hamao
Macrae & Co.
Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
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