Rna catalyst for cleaving specific rna sequences

Details Rna catalyst for cleaving specific rna sequences Rna catalyst for cleaving specific rna sequences

C - Chemistry, Metallurgy

12

N

167/202, 195/1.1

C12N 9/22 (2006.01) A61K 31/70 (2006.01) C07H 21/02 (2006.01) C12N 15/11 (2006.01) C12N 15/82 (2006.01)

Patent

CA 1340323

A synthetic RNA catalyst capable of cleaving an RNA substrate, the catalyst comprising a substrate binding portion and a "hairpin" portion. The invention also provides an engineered DNA molecule and a vector, each comprising a DNA sequence coding for an RNA catalyst according to the invention. The invention further comprises host cells transformed with the sectors of the invention which are capable of expressing the RNA substrate. Finally, the invention provides a method of cleaving an RNA substrate which comprises contacting the substrate with a synthetic RNA catalyst according to the invention.

611953

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