Process for preparing cephalosporin compounds

Details Process for preparing cephalosporin compounds Process for preparing cephalosporin compounds

C - Chemistry, Metallurgy

07

D

260/100, 260/271

C07D 463/00 (2006.01) C07D 501/04 (2006.01) C07D 505/00 (2006.01)

Patent

CA 1291118

ABSTRACT A process for preparing compounds of the formula I: Image (I) wherein X is sulphur, oxygen, methylene or sulphinyl (R or S configuration), R3 is hydrogen or methoxy, R4 is an optionally substituted (1-4C)alkyl group, Y is hydrogen or a carboxyl protecting group and Q is an optionally protected amino group or an acylamino group, which comprises reacting a compound of formula (II) Image (II) with a compound of formula (III) Image (III) wherein R4 is as defined above and W and Z represent hydrogen atoms or a group or groups removable to yield the compound of formula (I). The compounds of the formula I are useful intermediates in the preparation of cephalosporin antibiotics.

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