C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/251, 260/328
C07D 311/22 (2006.01) C07D 311/24 (2006.01) C07D 311/30 (2006.01) C07D 335/06 (2006.01) C07D 405/02 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01)
Patent
CA 1249273
ABSTRACT Novel chromone-8-aldehydes and thiochromone-8- aldehydes, useful in making pharmaceutically active dihydropyridines, of the formula Image in which R1 represents hydrogen, a C1-10 aliphatic hydrocarbon radical, a C1-C10 alkyl carboxylate, or an aromatic or heteroaromatic ring which optionally has 1-5 identical or different halogen C1-C10-alkyl, C1-C10-alkoxy, C1-C10- alkylthio, C1-C10-alkylsulphinyl, cyano, hydroxyl, nitro, C1-C5-monofluoroalkyl or polyfluoroalkyl, C1-C5 monofluoroalkoxy or polyfLuoroalkoxy, C1-C6 monofluoroalkylthio or polyfluoroalkylthio, amino, C1-C5-monoalkyl- amino or C1-C5 dialkylamino substituents, R2 represents hydrogen or 1 to 3 halogen atoms, A represents a single bond, a C1-C20 alkylene chain or a C2-C20 alkenylene chain which can optionally be interrupted by oxygen or sulphur, and X represents oxygen or sulphur, are made from corresponding compounds which in 8-position carry an ester or olefinic radical.
450363
Aktiengesellschaft Bayer
Fetherstonhaugh & Co.
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