G - Physics – 01 – N
Patent
G - Physics
01
N
167/129, 167/139
G01N 33/577 (2006.01) A61K 39/385 (2006.01) C07H 13/04 (2006.01) C07H 21/00 (2006.01) G01N 33/531 (2006.01) G01N 33/574 (2006.01)
Patent
CA 1194793
ABSTRACT: The invention relates to a process for producing a fucosyl antigen characterized in that an oligosaccharide containing an .alpha.-fucopyranosyl-(1?3)-, -(1?4)- or -(1?6)-galactopyranosyl group and serving as a hapten is reacted with a carrier protein to obtain a carbohydrate antigen and to a process for producing from the antigen an antibody having specific reactivity with cells of cancers of the digestive system, especially human colon carcinoma cells, and murine teratocarcinoma cells. The invention also relates to a method of determining a cancer associated carbohydrate linkage with use of such antibody capable of specifically recognizing specific carbohydrate linkage and to a cancer diagnosing kit containing the antibody.
429444
Chiba Taku
Miyauchi Tero
Muramatsu Takashi
Ozawa Masayuki
Sato Eiichi
Marks & Clerk
Otsuka Pharmaceutical Co. Ltd.
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