Transdermal delivery of highly ionized fat soluble drugs

Details Transdermal delivery of highly ionized fat soluble drugs Transdermal delivery of highly ionized fat soluble drugs

A - Human Necessities

61

M

128/104

A61M 37/00 (2006.01) A61K 9/70 (2006.01)

Patent

CA 1252361

ABSTRACT OF THE DISCLOSURE A medical device for the transdermal delivery of highly ionized, fat insoluble drugs comprises an aqueous drug reservoir having a physiological pH, said reservoir preferably being a gel maintained in an impermeable receptacle by a highly permeable support member disposed between the gel and a permeable contact adhesive. A permeation enhancer reservoir delivers a permeation enhancer to the skin through the aqueous reservoir and through a permeation enhancer release rate controlling membrane which is permeable to the permeation enhancer and impermeable to the drug and water. In a preferred embodiment the permeation enhancer release rate controlling membrane forms at least a portion of said receptacle.

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