Prostacyclin derivatives and their manufacture and use

Details Prostacyclin derivatives and their manufacture and use Prostacyclin derivatives and their manufacture and use

C - Chemistry, Metallurgy

07

D

260/235.01

C07D 307/935 (2006.01) C07D 307/937 (2006.01) C07D 405/06 (2006.01)

Patent

CA 1180701

ABSTRACT OF THE DISCLOSURE The present invention provides novel prostacyclin derivatives of the formula I Image (I) (in which R1 is the group -OR3 or -NHR4, R3 being H, optionally substituted alkyl, cycloalkyl or aryl or a heterocycle and R4 being an acid group, B is C1-10- aliphatic hydrocarbon, A is -CH2-CH2-, cis- or trans- -CH=CH- or -C?C-, W is optionally functionally modified -CHOH- or -C(CH3)OH-, D and E together are a direct bond or n is C1-5-alkylene and E is O or S or a direct bond, R2 is optionally substituted aliphatic hydrocarbon, cycloalkyl or aryl or a heterocycle and R5 is optionally functionally modified OH) and, when R1 is OH, salts thereof with bases and the manufacture of such compounds. The prostacy- clin derivatives and salts thereof have inter alia a hypotensive and may accordingly be made up into pharmaceutical preparations with suitable carriers.

316872

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