Reagent for detecting the presence and extent of periodontal...

Details Reagent for detecting the presence and extent of periodontal... Reagent for detecting the presence and extent of periodontal...

C - Chemistry, Metallurgy

12

Q

150/3.2, 150/15.

C12Q 1/37 (2006.01)

Patent

CA 1310893

- 1 - Abstract: The present invention is directed to a reagent for detecting the presence and extent of periodontal diseases which diagnoses or prognosticates contraction or progression of said diseases by determining aminopeptidase-like enzymatic activity in a specimen, said reagent comprises as a substrate for the enzyme either or both compounds of the formula: X-Z-Arg-Y (1) wherein Arg is an arginine residue; X is hydrogen or an amino blocking group; Y is a color developing group attached to the C-terminal of Arg; and Z is an amino acid or peptide residue composed of 1 to 4 amino acids or their blocked derivatives, the C-terminal of which is attached to the N- terminal of Arg, and X'-Z'-Pro-Y' (2) wherein Pro is a proline residue; X'is hydrogen or an amino blocking group; Y'is a color developing group attached to the C-terminal of Pro; and Z'is an amino acid or peptide residue composed of 0 to 4 amino acids or their blocked derivatives, the C-terminal of which is attached to the N- terminal of Pro.

543277

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