A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/48
A61K 49/02 (1985.01)
Patent
CA 1222692
ABSTRACT OF THE DISCLOSURE This invention relates to complexes of techne- tium 99m, stannous ion and novel derivatives of imino diacetic acid of the formula: Image wherein R1 is selected from the group consisting of: Image - 2 - Image or Image wherein X is halo (chloro, bromo or iodo) and R7 is lower alkyl of from 1-5 carbon atoms. It also relates to a novel diagnostic kit for hepatobiliary imaging comprising ingredients employed in the intravenous injection of a complex of technetium 99m, and an imino diacetic acid of the above formula. It also relates to a process for preparing said compounds by reaction of nitrilotriacetic acid anhydride and an amine of the formula R1NH2 wherein R1 is as defined hereinabove. The compounds of the present invention are useful as radioscintigraphic agents for diagnosis of hepatobiliary disease.
499167
Goudreau Gage Dubuc
Merck Frosst Canada & Co.
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