Cardiotonic thiazolones

Details Cardiotonic thiazolones Cardiotonic thiazolones

C - Chemistry, Metallurgy

07

D

167/231, 167/234

C07D 277/32 (2006.01) A61K 31/425 (2006.01) C07D 277/34 (2006.01) C07D 277/36 (2006.01) C07D 417/04 (2006.01)

Patent

CA 1276936

ABSTRACT Novel thiazolones of the formula: Image or a tautomer thereof, wherein Y is an oxygen or sulfur group; R1 is a hydrogen or a (C1-C5) alkyl group where R2 is R; R2 is a hydrogen or a (C1-C5) alkyl group where R1 is R; and R is a phenyl group optionally substituted wlth one or two members of the group consisting of (C1-C5) alkyl, (C1-C5) alkoxy, (C1-C5) alkyl- thio, (C1-C5) alkylsulfinyl, (C1-C5) alkulsul- fonyl, hydroxy, halogen, cyano, carboxy, carb(C1-C5)alkoxy, (C1-C5) alkanoylamino, imi- dazolyl or trifluoromethyl, or with a methyl- enedioxy group, or a 2-, 3- or 4-pyridyl group optionally substituted with a hydroxy, halogen, (C1-C5) alkyl, (C1-C5) alkoxy, (C1-C5) alkyl- thio, (C1-C5) alkylsulfinyl, (C1-C5) alkylsul- fonyl, cyano, carboxy, carb(C1-C5)alkoxy, (C1- C5)alkanoylamino or imidazolyl, or a 2- or 3- furanyl, 2- or 3-thienyl or 2- or 3-pyranyl group; enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure.

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