Method of diagnosing blood clots using fibrin-binding proteins

Details Method of diagnosing blood clots using fibrin-binding proteins Method of diagnosing blood clots using fibrin-binding proteins

C - Chemistry, Metallurgy

12

N

167/47, 530/5, 1

C12N 9/64 (2006.01) A61K 49/00 (2006.01) A61K 51/08 (2006.01) C07K 5/00 (2006.01)

Patent

CA 1335725

A fibrin-binding protein such as t-PA is labeled with a detectable substance, such as a radionuclide, and administered to a patient for diagnosis of blood clots and for monitoring the dissolution thereof during therapy. The detectable substance preferably is attached to t-PA through linkers which specifically bind to the portion of the t-PA protein responsible for enzymatic activity, thereby diminishing this activity while leaving the fibrin-binding property of the protein intact.

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