Method of reducing tissue damage at an inflammatory site...

Details Method of reducing tissue damage at an inflammatory site... Method of reducing tissue damage at an inflammatory site...

A - Human Necessities

61

K

167/139

A61K 39/395 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1317880

ABSTRACT A method of reducing tissue injury in humans or other animal species using a monoclonal antibody to inhibit specific phagocyte functions. The monoclonal antibody is selected to bind to phagocytic leukocytes for the purpose of inhibiting migration to an inflammatory site in the body and to inhibit the adhesion and spreading of activated leukocytes reaching such an area and then, block release of toxic substances by these cells. The monoclonal antibody is administered in vivo prior or early in the course of an ex- perience leading to an injurious inflammatory response such as can result from restoration of myocardial blood flow in- terrupted by an acute coronary thrombosis.

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