C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/151, 167/199
C07D 403/14 (2006.01) A61K 31/655 (2006.01) C07D 207/34 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01) C07H 5/06 (2006.01) C07H 15/26 (2006.01)
Patent
CA 1285934
A B S T R A C T =============== The invention relates to poly-4-aminopyrrole-2-carboxamido derivatives of the following formula Image wherein, subject to certain provisos, n is zero or an integer of 1 to 4; R is a) -NHR3, wherein R3 is a') -CON(NO)R4, in which R4 is C1-C4 alkyl either unsubstituted or substituted by halogen; or b') -CO(CH2)m-R5, in which R5 is halogen, oxiranyl, methyloxiranyl, aziridinyl, cyclopropyl or the residue of an alicyclic.alpha.,.beta.-unsaturated ketone or lactone, and m is zero or an integer of 1 to 4; b) Image wherein either R6 and R7 are the same and are each oxiranemethyl, aziridinemethyl, or C2-C4 alkyl 2-substituted by halogen or by a group -OSO2R8, wherein R8 is C1-C4 alkyl or phenyl, or one of R6 and R7 is hydrogen and the other is as defined above; c) -NO2; d) -NH2; or e) -NH-CHO; each group R1 is, independently, hydrogen or C1-C4 alkyl; R2 is a C1-C6 alkyl group terminating with a basic or acidic moiety or with a free or glycosilated hydroxy group, and the pharmaceutically acceptable salts thereof.
513760
Arcamone Federico
Mongelli Nicola
Penco Sergio
Fetherstonhaugh & Co.
Pharmacia & Upjohn S.p.a.
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