Modified meningococcal group b polysaccharide for conjugate...

Details Modified meningococcal group b polysaccharide for conjugate... Modified meningococcal group b polysaccharide for conjugate...

C - Chemistry, Metallurgy

12

P

167/135, 260/225

C12P 19/04 (2006.01) A61K 39/095 (2006.01) A61K 39/108 (2006.01)

Patent

CA 1261320

TITLE MODIFIED MENINGOCOCCAL GROUP B POLYSACCHARIDE FOR CONJUGATE VACCINE ABSTRACT OF TIIE DISCLOSURE The group B polysaccharide of Neisseria meningitidis is chemically modified to enhance the immune response thereto, thereby providing cross-reactive antibodies of high affinity. The N-acetyl group of the sialic acid residues of the polysaccharide has been substituted by the N-propionyl group, and this modified antigen then conjugated to a physiologically-acceptable protein such as tetanus toxoid. This conjugate vaccine has been found to raise high titers of high affinity group B IgG antibodies and would be useful against meningitis caused by group B N. meningitidis or by E. coli Kl organisms.

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