Ring open nucleoside analogues

C - Chemistry – Metallurgy – 07 – D

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C07D 239/28 (2006.01) C07D 239/46 (2006.01) C07D 239/54 (2006.01) C07D 239/553 (2006.01) C07D 251/12 (2006.01) C07D 251/16 (2006.01) C07D 473/00 (2006.01) C07D 473/02 (2006.01) C07D 473/18 (2006.01) C07F 7/18 (2006.01) C07F 9/6512 (2006.01) C07F 9/6561 (2006.01) C07H 19/10 (2006.01) C07H 19/20 (2006.01)

Patent

CA 1305137

ABSTRACT OF THE DISCLOSURE Nucleoside analogues having a ring-open structure, of general formula: Image where R and R' may be hydrogen, silyl groups, substituted alkyl groups, benzyl groups and the like, and X is an optionally substituted base such as guanine or adenine, have been shown to exhibit anti-viral and other biological activities at non-toxic levels. Also provided are phosphate-linked dinucleotide compounds of similar structures.

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