Diphosphonic acid derivatives, processes for the preparation...

Details Diphosphonic acid derivatives, processes for the preparation... Diphosphonic acid derivatives, processes for the preparation...

C - Chemistry, Metallurgy

07

F

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C07F 9/547 (2006.01) A61K 31/675 (2006.01) C07F 9/6506 (2006.01) C07F 9/6518 (2006.01) C07F 9/653 (2006.01) C07F 9/6539 (2006.01) C07F 9/6541 (2006.01)

Patent

CA 1338895

Alkyldiphosphonic acid derivatives of the general formula: Image (I) wherein Het is a heteroaromatic five-membered ring con- taining 2 to 3 heteroatoms which can be partly hydro- genated and optionally substituted one or more times by alkyl, alkoxy, phenyl cyclohexyl, cyclohexylmethyl, halogen or amino, whereby two adjacent alkyl sub- stituents can together also form a ring, X is a hydro- gen atom, a hydroxyl group or an amino group optionally substituted by lower alkyl and R is a hydrogen atom or a lower alkyl radical, with the proviso that Het is not a pyrazole ring; as well as the pharmacologically acceptable salts thereof, are useful in the treatment of calcium metabolism disturbances, for example, treat- ment of osteoporosis; processes for the preparation of the compounds and pharmaceutical compositions contain- ing them are also described.

543290

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