Surfactant and pharmaceutical compositions containing same

Details Surfactant and pharmaceutical compositions containing same Surfactant and pharmaceutical compositions containing same

A - Human Necessities

61

K

167/104

A61K 35/42 (2006.01) A61K 9/00 (2006.01) A61K 31/66 (2006.01) A61K 38/17 (2006.01)

Patent

CA 1208129

SURFACTANT AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME ABSTRACT OF THE DISCLOSURE A surfactant having the capacity of reducing the surface tension in pulmonary alveoli significantly is provided. The surfactant consists essentially of, based on the total weight of the surfactant, 50.6-85.0% of a choline phospho- glyceride, 4.5-37.6% of an acid phospholipid, 4.6-24.6% of a fatty acid or its analogue and 0.1-10.0% of a lipoprotein derived from the lung of a mammal. These components co- operate to form a kind of film at a gas-liquid interface, within pulmonary alveoli and reduce the surface tension. A pharmaceutical composition comprising the surfactant is useable for the clinical treatment of respiratory distress syndrome.

449223

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